NTCP Models Reference

PyPlanAnalysis bundles 25 published NTCP (Normal Tissue Complication Probability) models, mostly for brain / head-and-neck proton therapy toxicity endpoints. Each is implemented as one NTCP__* function in PyPlanAnalysis.NTCP, driven by metadata (organ-at-risk, DVH/LVH metric inputs, fitted coefficients) stored in the bundled NTCPModels_params.xlsx workbook.

Selecting models

Pass the desired model names to NTCPConfig:

from PyPlanAnalysis import NTCPConfig

cfg = NTCPConfig(models=["BrainNecrosis_5y", "HearingLoss_late"])
ntcp = results.CalcNTCP(cfg)

The models list must use the workbook’s model_name values (the part of each function name after NTCP__), e.g. "BrainNecrosis_5y" for NTCP__BrainNecrosis_5y().

Available models

Function	Endpoint	Timing	Reference	Parameters
NTCP__Alopecia_G1_12m__1()	Alopecia grade >=1, 12 months after PBT	Late	Dutz et al. 2021	beta_0, beta_1
NTCP__Alopecia_G1_12m__2()	Alopecia grade ≥1_12 months after PBT	Late	Dutz et al. 2021	beta_0, beta_1
NTCP__Alopecia_G1_24m__1()	Alopecia grade ≥1_24 months after PBT	Late	Dutz et al. 2021	beta_0, beta_1
NTCP__Alopecia_G1_24m__2()	Alopecia grade ≥1_24 months after PBT	Late	Dutz et al. 2021	beta_0, beta_1
NTCP__Alopecia_G1_acute()	Alopecia grade >=1 (CTCAE, Common Terminology Criteria for Adverse Events)	Acute	Dutz et al. 2019	beta_0, beta_1
NTCP__Alopecia_G2_acute()	Alopecia grade >=2 (CTCAE, Common Terminology Criteria for Adverse Events)	Acute	Dutz et al. 2019	beta_0, beta_1
NTCP__Blindness_5y()	Blindness	5 years post-RT	Burman et al. 1991	TD50, m
NTCP__BrainNecrosis_5y()	Brain necrosis	5 years post-RT	Bender et al. 2012	D50, gamma
NTCP__CataractRequiringIntervention_5y()	Cataract requiring intervention	5 years post-RT	Burman et al. 1991	TD50, m
NTCP__DelayedRecall_1_5y()	Delayed recall (on Wechsler Memory scale III Word Lists)	1.5 years post-RT	Gondi et al. 2012	EQD_2_50, m
NTCP__EndocrineDysfunction_late()	Endocrine dysfunction (CTCAE, Common Terminology Criteria for Adverse Events)	At least 0.5 – 2 years post-RT	De Marzi et al. 2015	TD50, gamma50
NTCP__Erythema_G1_acute()	Erythema grade ≥ 1	Acute	Dutz et al. 2019	beta_0, beta_1
NTCP__Erythema_G2_acute()	Erythema grade ≥ 2 (CTCAE, Common Terminology Criteria for Adverse Events)	Acute	Dutz et al. 2019	beta_0, beta_1
NTCP__Fatigue_G1_24m()	Fatigue grade ≥ 1_24 months after PBT	Late	Dutz et al. 2021	beta_0, beta_1, beta_2
NTCP__Fatigue_G1_acute()	Fatigue grade >=1 (CTCAE, Common Terminology Criteria for Adverse Events)	Acute	Dutz et al. 2019	beta_0, beta_1, beta_2
NTCP__HearingImpairment_G1_12m__1()	Hearing impairment grade ≥1_12 months after PBT	Late	Dutz et al. 2021	beta_0, beta_1
NTCP__HearingImpairment_G1_12m__2()	Hearing impairment grade ≥1_12 months after PBT	Late	Dutz et al. 2021	beta_0, beta_1, beta_2
NTCP__HearingImpairment_G1_24m()	Hearing impairment grade ≥1_24 months after PBT	Late	Dutz et al. 2021	beta_0, beta_1
NTCP__HearingLoss_late()	Hearing loss (CTCAE, Common Terminology Criteria for Adverse Events)	At least 0.5 – 2 years post-RT	De Marzi et al. 2015	TD50, gamma50
NTCP__MemoryImpairment_G1_12m()	Memory impairment grade ≥1_12 months after PBT	Late	Dutz et al. 2021	beta_0, beta_1
NTCP__MemoryImpairment_G1_24m()	Memory impairment grade ≥1_24 months after PBT	Late	Dutz et al. 2021	beta_0, beta_1
NTCP__MemoryImpairment_G2_12m()	Memory impairment grade ≥2_12 months after PBT	Late	Dutz et al. 2021	beta_0, beta_1
NTCP__OcularToxicity_G2_acute()	Ocular toxicity grade ≥ 2 (RTOG, Radiation Therapy Oncology Group)	Acute	Batth et al. 2013	beta_0, beta_1
NTCP__TemporalLobeInjury_5y()	Temporal lobe injury	5 years post-RT	Kong et al. 2016	beta_0, beta_1
NTCP__Tinnitus_G2_late()	Tinnitus grade ≥ 2 (LENT-SOMA, late effects of normal tissues - subjective, objective, management)	1–2 years post-RT	Lee et al. 2015	TD50, m